Medical applications of polyacrylamide

Medical applications of polyacrylamide
Polyacrylamide gel can be utilized as non-thrombinogen granulation agent, surgical, contact lens raw material, microcapsule outer coating material, and for manufacturing superior hemostatic sponges, sanitary napkins, and diapers. Polyacrylamide with a grain size ranging from hundreds of microns to tens of microns can be applied as chromatographic packing (e.g., gel column packing), effectively separating spherical proteins like cytochrome. It further enables protein desalination, concentration. Polyacrylamide resin reacted with Mannich reaction, introducing L-proline or L-hydroxyproline onto the amide side chain via methylene bridge, forming chiral ligand resin that efficiently resolves DL-amino acids. The resultant polyvinylamine resin containing chiral amino acids complexed with copper ions serves as a stationary phase in ligand exchange chromatography, resolving a range of amino acids, especially aromatic ones, due to its strong hydrophilic backbone, significantly shortening resolution time.